Researchers from The Australian National University (ANU) have discovered a previously unknown ability of a group of immune system cells, known as Atypical B cells (ABCs), to fight infectious diseases such as malaria. 

The scientists say ABCs could also be key to developing new treatments for chronic autoimmune conditions such as lupus. 

The discovery provides new insight into how the immune system fights infections and brings scientists a step closer to harnessing the body’s natural defences to combat malaria. 

According to the researchers, ABCs have long been associated with malaria, as malaria patients have more of these cells in their system compared to the general population. 

“In this study, we wanted to understand the mechanisms that drive the creation of ABCs in the immune system, but also find out whether these cells are good or bad for us when it comes to fighting infection,” lead author Dr Xin (Andy) Gao, from the ANU Division of Immunology and Infectious Diseases, said. 

“Although ABCs are known to contribute to chronic inflammatory diseases and autoimmunity, we’ve discovered a previously unknown ability of these cells to fight disease. In this sense, ABCs are like a double-edged sword. 

“Contrary to past belief, ABCs are not junk cells; they are more important than we thought. 

“Our research found that ABCs are also instrumental in developing T follicular helper cells. These helper cells generate powerful antibodies that help the body fight malaria parasites. 

“Antibodies can block parasites in the blood as they travel from the site of the infectious mosquito bite to the liver, where the infection is first established.” 

Dr Xin Gao looks through a microscope.
Professor Ian Cockburn and Dr Xin Gao examine a box of mosquitos that the scientists are studying as part of their research efforts to find longer-lasting treatments for malaria.

ANU scientists say targeting ABCs could also pave the way for new lupus treatments. Photo: Jack Fox/ANU

In 2022, malaria killed more than 600,000 people worldwide. Although the disease is preventable and curable, scientists face an uphill battle to find long-lasting treatments as malaria parasites continue to find new ways to build resistance to current therapies. 

Using gene-editing technology on mice, the ANU researchers discovered a gene called Zeb2 is crucial to the production of ABCs. 

“We found that manipulating the Zeb2 gene disrupted the creation of ABCs in the immune system,” study co-author Professor Ian Cockburn, also from ANU, said. 

“Importantly, we found that mice without the Zeb2 gene were unable to control malaria infection. 

“Therefore, the findings show that ABCs play a crucial role in fighting malaria infections.” 

The researchers say targeting ABCs could also pave the way for new treatments for autoimmune diseases such as lupus. 

“ABCs also appear in large numbers in many autoimmune diseases, including lupus, which can be life-threating in severe cases,” Professor Cockburn said. 

“By developing a better understanding of the role of ABCs in the immune system and the cells’ role in fighting disease, it could bring us a step closer to one day developing new and more effective therapies.” 

The research is published in Science Immunology

The ANU Division of Immunology and Infectious Diseases is at the forefront of major scientific breakthroughs in the fight against malaria. Read more at ANU Reporter 

Top image: Dr Xin Gao (pictured) says ABCs are not ‘junk cells’ – they actually play a crucial role in helping the body fight diseases such as malaria. Photo: Jack Fox/ANU

Contact the media team

George Booth

Senior Media and Communications Officer

You may also like

Article Card Image

Former NZ PM Helen Clark: ‘Raise issues, never give up.’

Inequality is a major public health issue, but advocates can make a difference, the former New Zealand prime minister says.

Article Card Image

How daylight saving affects your sleep and what you can do about it 

Daylight saving has a long history and surprising health risks. But little hacks can help us feel well when the clock changes.

Article Card Image

Connection the key to retaining rural GPs

A supportive workplace, work-life balance and a connection to rural communities are all key to retaining doctors in…

Subscribe to ANU Reporter

Anu Logo

+61 2 6125 5111

The Australian National University, Canberra

CRICOS Provider: 00120C

ABN: 52 234 063 906

EDX Logo
Group of eight Australia Logo